Synthesis of C-oxetanosyl-thiazole and its carbocyclic analog nucleosides as potential chemotherapeutic agents

DOI: 10.1016/0960-894X(96)00340-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1897 - 1900 (1996)

Update date:2022-07-29

Topics:

Authors:

Kikuchi, Yoshiko

Nishiyama, Shigeru

Yamamura, Shosuke

Kato, Kuniki

Fujiwara, Sari

Umezawa, Kazuo

Terada, Yukimasa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00340-X

Novel C-nucleosides (2'S, 3'S)-2-[2',3'-(bishydroxymethyl)-oxetan-1'-yl]-1,3-thiazole-4-carboxam ide 3 and its carbocyclic analog 4 have been synthesized. Compound 4 enhanced NGF-induced differentiation on PC12 cells at 100 μg/ml, and moreover, 4 alone also induced morphological differentiation significantly at 10 and 100 μg/ml.

Full text of DOI:10.1016/0960-894X(96)00340-X

Products guided by the article

Product name:C₂₀H₁₉NO₆

Cas No:182686-25-5

R&D Labs maybe for 182686-25-5

GenicBio Limited

Contact:+86-(0)21-3770 9035

Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Daicel Chiral Technologies (China)CO.,LTD

Contact:021-5046-0086*8

Address:Part C, FL 5, the 16th Building, No. 69, XiYa Road, WaiGaoQiao Free Trade Zone, Shanghai, 200131, P.R.China
puyang hongda shengdao new material co.,ltd.

Contact:+86-393- 4896278

Address:No.29 East Zhongyuan Road
GLD peptide scientific lnc.

Contact:21-7631221 15884421033

Address:326 Science and technology,Shanghai,China
Guangzhou Probig Fine Chemical Co., Ltd.

Contact:020-86297874

Address:No.2, 1/F, No.20, Hetai Road,Hebian Village, Baiyun District,Guangzhou,China

Relevant to this article

Pyrido[2,3-d]pyrimidines, II [1]. One Step Synthesis of Pyrido[2,3-d]pyrimidines and Pyrimido[4,5-b]quinolines from 6-Amino Uracils

Doi:10.1007/BF00807031
(1996)
Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives

Doi:10.1021/jm960507d
(1996)
Structure elucidation via stereoselective synthesis of the acetate center of 1-azabicyclo[2.2.2]oct-3-yl α-hydroxy-α-(1-iodo-1-propen-3-yl)-α-phenylacetate (IQNP). A high affinity muscarinic imaging agent for SPECT

Doi:10.1021/jo961033t
(1996)
Synthesis and evaluation of trimetoquinol derivatives: Novel thromboxane A₂/prostaglandin H₂ antagonists with diminished β-adrenergic agonist activity

Doi:10.1021/jm950896w
(1997)
An efficient and simple entry to N-substituted β-enamino acid derivatives from 2-alkyl-2-oxazolines and 2-alkyl-2-thiazolines

Doi:10.1021/jo961037y
(1996)
Doi:10.1007/BF00844218
()

Article Doi