Synthesis of C-oxetanosyl-thiazole and its carbocyclic analog nucleosides as potential chemotherapeutic agents

DOI: 10.1016/0960-894X(96)00340-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1897 - 1900 (1996)

Update date:2022-07-29

Topics:

Authors:

Kikuchi, Yoshiko

Nishiyama, Shigeru

Yamamura, Shosuke

Kato, Kuniki

Fujiwara, Sari

Umezawa, Kazuo

Terada, Yukimasa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00340-X

Novel C-nucleosides (2'S, 3'S)-2-[2',3'-(bishydroxymethyl)-oxetan-1'-yl]-1,3-thiazole-4-carboxam ide 3 and its carbocyclic analog 4 have been synthesized. Compound 4 enhanced NGF-induced differentiation on PC12 cells at 100 μg/ml, and moreover, 4 alone also induced morphological differentiation significantly at 10 and 100 μg/ml.

Full text of DOI:10.1016/0960-894X(96)00340-X

Products guided by the article

Product name:C₂₀H₁₉NO₆

Cas No:182686-25-5

R&D Labs maybe for 182686-25-5

Taiwan Surfactant Corp.

Contact:886 2 2541 0022

Address:8 Fl., No. 11, Sec. 1, Chung Shan North Rd., Taipei, Taiwan R.O.C.
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

website:http://www.shydtec.com

Contact:86-21-57721279

Address:Science and Technology Park, Songjiang District, Shanghai, China
APOLLO HEALTHCARE RESOURCES

Contact:+65 9658 0999

Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Hunan Haili Chemical Industry Co.,Ltd.

Contact:+86-731-85521860

Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China

Relevant to this article

Pyrido[2,3-d]pyrimidines, II [1]. One Step Synthesis of Pyrido[2,3-d]pyrimidines and Pyrimido[4,5-b]quinolines from 6-Amino Uracils

Doi:10.1007/BF00807031
(1996)
Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives

Doi:10.1021/jm960507d
(1996)
Structure elucidation via stereoselective synthesis of the acetate center of 1-azabicyclo[2.2.2]oct-3-yl α-hydroxy-α-(1-iodo-1-propen-3-yl)-α-phenylacetate (IQNP). A high affinity muscarinic imaging agent for SPECT

Doi:10.1021/jo961033t
(1996)
Synthesis and evaluation of trimetoquinol derivatives: Novel thromboxane A₂/prostaglandin H₂ antagonists with diminished β-adrenergic agonist activity

Doi:10.1021/jm950896w
(1997)
An efficient and simple entry to N-substituted β-enamino acid derivatives from 2-alkyl-2-oxazolines and 2-alkyl-2-thiazolines

Doi:10.1021/jo961037y
(1996)
Doi:10.1007/BF00844218
()

Article Doi