Synthesis of C-oxetanosyl-thiazole and its carbocyclic analog nucleosides as potential chemotherapeutic agents

DOI: 10.1016/0960-894X(96)00340-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1897 - 1900 (1996)

Update date:2022-07-29

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Authors:

Kikuchi, Yoshiko

Nishiyama, Shigeru

Yamamura, Shosuke

Kato, Kuniki

Fujiwara, Sari

Umezawa, Kazuo

Terada, Yukimasa

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Article abstract of DOI:10.1016/0960-894X(96)00340-X

Novel C-nucleosides (2'S, 3'S)-2-[2',3'-(bishydroxymethyl)-oxetan-1'-yl]-1,3-thiazole-4-carboxam ide 3 and its carbocyclic analog 4 have been synthesized. Compound 4 enhanced NGF-induced differentiation on PC12 cells at 100 μg/ml, and moreover, 4 alone also induced morphological differentiation significantly at 10 and 100 μg/ml.

Full text of DOI:10.1016/0960-894X(96)00340-X

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