Studies on the reactivity of cephalosporins. 6. Ozonolysis of Δ2-cephem derivatives as a new entry to highly functionalized 2-oxoazetidine and 2-oxoazetidine-4-sulfenic acid derivatives

Article abstract of DOI:10.1016/0040-4020(96)00555-8

The ozonolysis of Δ²-cephem derivatives 1, 2, and 3, to obtain highly functionalized 2-oxoazetidine and 2-oxoazetidine-4-sulfenic acid derivatives is described. An efficient and selective synthesis of the oxapenem derivative 16 is also reported