A facile preparation of amino(diethoxyphosphoryl)acetic esters: Transformation of phosphoranes to phosphonic esters

DOI: 10.1055/s-1996-4271

Source and publish data:

Synthesis p. 580 - 582 (1996)

Update date:2022-08-03

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Authors:

Seki, Masahiko

Matsumoto, Kazuo

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Article abstract of DOI:10.1055/s-1996-4271

Triethoxyphosphoranes 8, generated in situ by the treatment of oxalylcarbamates 7 with triethyl phosphite, were reacted with bromotrimethylsilane or hydrogen bromide in acetic acid to afford diethyl phosphonates 9 in high yields. These were readily converted into amino(diethoxyphosphoryl)acetic esters 10 by hydrogenation.

Full text of DOI:10.1055/s-1996-4271

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