A facile preparation of amino(diethoxyphosphoryl)acetic esters: Transformation of phosphoranes to phosphonic esters

DOI: 10.1055/s-1996-4271

Source and publish data:

Synthesis p. 580 - 582 (1996)

Update date:2022-08-03

Topics:

Authors:

Seki, Masahiko

Matsumoto, Kazuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1996-4271

Triethoxyphosphoranes 8, generated in situ by the treatment of oxalylcarbamates 7 with triethyl phosphite, were reacted with bromotrimethylsilane or hydrogen bromide in acetic acid to afford diethyl phosphonates 9 in high yields. These were readily converted into amino(diethoxyphosphoryl)acetic esters 10 by hydrogenation.

Full text of DOI:10.1055/s-1996-4271

Products guided by the article

Product name:(Benzyl-benzyloxycarbonyl-amino)-oxo-acetic acid ethyl ester

Cas No:180790-10-7

R&D Labs maybe for 180790-10-7

SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD

website:http://www.jinjingroup.com

Contact:86-574-13989382828

Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Acros Pharmatech Limited

website:http://www.acrospharmatech.com

Contact:+1-3234804688

Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Shanghai Sinofluoro Scientific Co., Ltd

Contact:+86-21-64279360

Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
ZCIC INTERNATIONAL LTD

Contact:+86-512-56795332

Address:No227 Shuanglong Rd, Fenghuang, Zhangjiagang

Relevant to this article

Synthesis of isotopically labelled DNA degradation products for use in mass spectrometric studies of cellular DNA damage

Doi:10.1002/(SICI)1099-1344(199608)38:8<713::AID-JLCR886>3.0.CO;2-I
(1996)
The preparation of dialkylthiophosphonatoamines. X-ray structures of (EtO)₂PSNHC₆H₄NO₂ and [(EtO)₂PSNHC₆H₄NO₂] ₂PdCl₂

Doi:10.1016/0277-5387(96)00119-2
(1996)
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N⁵-substituted glutamine analogs

Doi:10.1248/cpb.44.1498
(1996)
Palladium-mediated intramolecular cyclization of substituted pentynoic acids. A new route to γ-arylidenebutyrolactones

Doi:10.1016/0040-4039(96)00063-9
(1996)
Synthesis, Biological Activity, and Quantitative Structure-Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives

Doi:10.1021/jm0310784
(2004)
Synthesis of optically active regioregular polythiophenes and their self-organization at the air-water interface

Doi:10.1021/la4015527
(2013)

Article Doi