Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N5-substituted glutamine analogs

DOI: 10.1248/cpb.44.1498

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1498 - 1509 (1996)

Update date:2022-08-03

Topics:

Authors:

Itoh, Fumio

Yoshioka, Yoshio

Yukishige, Koichi

Yoshida, Sei

Wajima, Megumi

Ootsu, Koichiro

Akimoto, Hiroshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.44.1498

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3- d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351) and related compounds was replaced with some N⁵-substituted glutamines. Antifolates (4A-S) were effectively prepared

Full text of DOI:10.1248/cpb.44.1498

NII-Electronic Library Service

Products guided by the article

Product name:(S)-2-tert-Butoxycarbonylamino-4-(2-hydroxy-phenylcarbamoyl)-butyric acid methyl ester

Cas No:181622-61-7

R&D Labs maybe for 181622-61-7

chengdu firsterchem Pharmaceutical Co., Ltd.

Contact:028-66825849

Address:chengdu
WEIFANG DERUN CHEMICAL CO.,LTD

Contact:86-536-8956886

Address:weifang
Shuanghe Bio-Technology Limited(expird)

Contact:+86-571-61710758,18968016640

Address:Jinqiao north road 916# Fuyang
Zhushan County Tianxin Pharmaceutical & Chemical Co., Ltd.

Contact:0086-719-4224892

Address:Tutang Road, Chengguan Town, Zhushan County, Hubei Province
Shanghai UCHEM Inc.

Contact:+86-21-56338808

Address:799 Dunhuang Road, Putuo

Relevant to this article

Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis

Doi:10.1021/jm200036n
(2011)
An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption

Doi:10.1002/anie.200460348
(2004)
Fluorescent phosphane selenide as efficient mercury chemodosimeter

Doi:10.1021/ol200066p
(2011)
Interaction of alkoxides. XVIII. Utilitization of the complex base from alkyllithium and potassium alkoxides in the dimetallation of phenol, thiophenol, o-, m- and p-cresol

Doi:10.1016/0022-328X(90)85160-Z
(1990)
Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

Doi:10.1016/j.ejmech.2021.113330
(2021)
Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes

Doi:10.1039/c0gc00725k
(2011)

Article Doi