Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. II. Synthesis and antitumor activity of N5-substituted glutamine analogs

DOI: 10.1248/cpb.44.1498

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1498 - 1509 (1996)

Update date:2022-08-03

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Authors:

Itoh, Fumio

Yoshioka, Yoshio

Yukishige, Koichi

Yoshida, Sei

Wajima, Megumi

Ootsu, Koichiro

Akimoto, Hiroshi

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Article abstract of DOI:10.1248/cpb.44.1498

The glutamic acid moiety of N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3- d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351) and related compounds was replaced with some N⁵-substituted glutamines. Antifolates (4A-S) were effectively prepared

Full text of DOI:10.1248/cpb.44.1498

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