A novel and general route to diverse A-ring aromatic trichothecanes via cyclobutanes

Article abstract of DOI:10.1016/0040-4020(96)00549-2

A novel and generally applicable approach to A-ring aromatic trichothecane 2 was achieved by the regiocontrolled cyclization of 25, 26, 29, and 30 as a key step, followed by stereoselective construction of the epoxide ring. This manuscript also described the regiocontrolled ring expansion of the olefinic cyclobutanols 19-22 to give the enones 23 and 24 which were the important intermediates in this approach.