Palladium-catalyzed cross-coupling reactions of arylmetal compounds with β-substituted α-iodoenones and a cyclohexyl triflate

Article abstract of DOI:10.1016/0040-4020(96)00489-9

Electron-rich arylstannanes were found to couple with α-iodoenones in the presence of Pd₂(dba)₃ CHCl₃, a weak-coordinating ligand [AsPh₃ or Pd(o-tol)₃] and Cul (0.75-1.0 equiv) to give sterically hindered α- arylcyclohexenones 15-20. In addition, compounds 19, 22 and 23 were prepared by Suzuki coupling reactions of the cyclohexyl derivatives 7c,f and 11, respectively, with the arylboronic acid 21.