An expeditious synthesis of a biscyclam with an aromatic linker

Article abstract of DOI:10.1016/0040-4039(96)01097-0

An efficient synthesis of 1 starting from N,N'-bis(3-aminopropyl)ethylenediamine 2 is described. Two salient features of the present work are the selective bis or tris-trifluoroacetylation of 2 and a novel bis-macrocyclization of the hexatosyl intermediate 5 using ethylene glycol ditosylate.