Cis- and trans-1,7,9-trioxadispiro[5.1.5.3]hexadecane: Synthetic studies

Article abstract of DOI:10.1016/0040-4039(96)01165-3

The first synthesis of the title compounds via thermodynamic spirocyclization of a diketodiol 2 is described. Three convergent synthetic approaches to protected derivatives of 2 have been developed, all of which have been converted into a 1.70:1.00 mixtur