Australian Journal of Chemistry p. 647 - 650 (1996)
Update date:2022-08-05
Topics:
Barlin, Gordon B.
Kotecka, Barbara
Rieckmann, Karl H.
A series of 10 pyrimethamine analogues containing 3′- and 4′-trifluoromethyl and 3′,4′-methylenedioxy groups has been prepared and tested for in vitro antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine, they were much less active against the drug-resistant K-1 isolate. The 4′-trifluoromethyl compunds, however, showed much smaller differences.
View MoreQingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Jinan Hongfangde Pharmatech Co.,Ltd
Contact:86-531-88870908
Address:F Bldg. West Unit North Area of Univ. Tech. Garden Xinyu Rd. Jinan New & High Tech Industry Development Zone Shandong, China
Changsha Kamer Essence and Flavor Co.,Ltd
Contact:86-731-89832270
Address:No.327 Kangnin Road Changsha Bio Information Industry Park, Changsha city, Hunan province
Contact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
Refine Chemicals Science & Technology Technology Developing Co., Ltd.
Contact:+86-22-87899130
Address:No.12,west keyan road,Tianjin City
Doi:10.1246/bcsj.69.2967
(1996)Doi:10.1021/jm980280h
(1998)Doi:10.1246/cl.1997.111
(1997)Doi:10.1055/s-1996-4359
(1996)Doi:10.1002/(SICI)1099-0690(199901)1999:1<251::AID-EJOC251>3.0.CO;2-M
(1999)Doi:10.1016/S0960-894X(01)00810-1
(2002)