Solution phase combinatorial chemistry. I. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries

Article abstract of DOI:10.1016/0040-4039(96)01627-9

Three novel unsymmetrical polyazacyclophane scaffolds 1-3 were efficiently synthesized in high yields by a new cyclization method followed by selective deprotection. Scaffold 2 was combinatorialized by solution phase simultaneous addition of functionaliti