Ring-based analogues of pentamidine versus P. carinii pneumonia in culture

Article abstract of DOI:10.1016/0960-894X(96)00427-1

The synthesis of aromatic ring-based pentamidine analogues, in which the aliphatic bridge has been replaced by benzene, pyridine, or pyrimidine has been accomplished in two steps. Compounds containing benzene and pyridine as the central core of the molecule have demonstrated activity against PCP in culture.