
Chemical and Pharmaceutical Bulletin p. 2186 - 2188 (1996)
Update date:2022-08-05
Topics:
Nemoto, Hisao
Kikuishi, Junya
Shibuya, Masayuki
Conversion of the phthalide derivative 5 to the enediynes 6 and 11 are described. Treatment of 5 with 1,8-diazabicyclo[5.4.0]undec-7-ene in hexamethylphosphoric triamide stereoselectively gives 6, which can be used as an efficient DNA-damaging biradical.
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Doi:10.1016/S0031-9422(96)00431-1
(1996)Doi:10.1039/jr9650003645
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(2012)