A new method for the preparation of phenyl-substituted cis-enediyne from a phthalide derivative

DOI: 10.1248/cpb.44.2186

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2186 - 2188 (1996)

Update date:2022-08-05

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Authors:

Nemoto, Hisao

Kikuishi, Junya

Shibuya, Masayuki

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Article abstract of DOI:10.1248/cpb.44.2186

Conversion of the phthalide derivative 5 to the enediynes 6 and 11 are described. Treatment of 5 with 1,8-diazabicyclo[5.4.0]undec-7-ene in hexamethylphosphoric triamide stereoselectively gives 6, which can be used as an efficient DNA-damaging biradical.

Full text of DOI:10.1248/cpb.44.2186

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