Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

DOI: 10.1016/S0960-894X(96)00494-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2725 - 2728 (1996)

Update date:2022-08-03

Topics:

Authors:

Nishikawa, Naoyuki

Komazawa, Hiroyuki

Orikasa, Atsushi

Yoshikane, Mitsuo

Yamaguchi, Jiro

Kojima, Masayoshi

Ono, Mitsunori

Itoh, Isamu

Azuma, Ichiro

Fujii, Hideki

Murata, Jun

Saiki, Ikuo

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Article abstract of DOI:10.1016/S0960-894X(96)00494-5

Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.

Full text of DOI:10.1016/S0960-894X(96)00494-5

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