Synthesis and reactivity of a 3-vinylidenepiperidine as a model study of α-allenic amines

Article abstract of DOI:10.3987/com-96-7563

4-Acetonyl-1-benzyl-3-vinylidenepiperidine (8), prepared by cyclization of propargylic silane (7), was used as a model to study the usefulness of the allene moiety as a precursor of the two-carbon chain present in the piperidine ring of Strychnos alkaloids.