
Tetrahedron p. 14397 - 14410 (1997)
Update date:2022-08-03
Topics:
Suau, Rafael
Lopez-Romero, Juan Manuel
Rico, Rodrigo
The reaction of biphenyl acetamides with excess of oxalyl chloride/stannyl chloride offers a one pot, high-yield entry to 4,5-dioxoaporphine alkaloids. This strategy has been applied to the synthesis of 4,5-dioxodehydrocorydine starting from 1-iodo-2,3-dimethoxybenzene. The cytotoxicity of tetraoxygenated 4,5-dioxoaporphines has been evaluated.
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