Toward the total synthesis of hygrolidin: Stereocontrolled construction of the C1-C17 seco-acid fragment and the C18-C25 masked hemiacetal subunit

Article abstract of DOI:10.1016/S0040-4039(96)02132-6

Toward the first total synthesis of 16-membered macrolide antibiotic hygrolidin, the C1-C17 seco-acid fragment and the C18-C25 masked hemiacetal subunit as potential precursors have been synthesized in enantiomerically homogeneous forms. Copyright (C) 199