Enantioselective synthesis of the lactone moiety of HMG-CoA reductase inhibitor: Stereoselective synthesis of (+)-(4R,6R)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one

DOI: 10.1016/S0957-4166(96)00525-3

Source and publish data:

Tetrahedron Asymmetry p. 181 - 184 (1997)

Update date:2022-07-30

Topics:

Authors:

Honda, Toshio

Ono, Satoko

Mizutani, Hirotake

Hallinan, Keith O.

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Article abstract of DOI:10.1016/S0957-4166(96)00525-3

The enantioselective synthesis of the lactone moiety of (+)-compactin and (+)-mevinolin was established starting from a meso-3,5-dihydroxycyclohexanone derivative by employing an enantioselective deprotonation strategy.

Full text of DOI:10.1016/S0957-4166(96)00525-3

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