Enantioselective synthesis of the lactone moiety of HMG-CoA reductase inhibitor: Stereoselective synthesis of (+)-(4R,6R)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one

Article abstract of DOI:10.1016/S0957-4166(96)00525-3

The enantioselective synthesis of the lactone moiety of (+)-compactin and (+)-mevinolin was established starting from a meso-3,5-dihydroxycyclohexanone derivative by employing an enantioselective deprotonation strategy.