Tetrahedron Letters p. 1037 - 1040 (1997)
Update date:2022-08-04
Topics:
Clemencin-Le Guillou, Claire
Giorgi-Renault, Sylviane
Quirion, Jean-Charles
Husson, Henri-Philippe
New quinolones 3, 6 and 9 annelated to either a 5-membered or a 6-membered lactose were designed as hybrids of antibacterial 4-quinolones and antitumor epipodophyllotoxin derivatives. They were synthesized using ethyl 2-ethenyl-4-hydroxy-1,2-dihydroquinoline-3-carboxylate 2 as a key intermediate.
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(1997)
