Asymmetric synthesis and absolute stereochemistry of 4,4-bis(trifluoromethyl)imidazoline based ACAT inhibitors

DOI: 10.1016/S0040-4020(97)00081-1

Source and publish data:

Tetrahedron p. 5359 - 5372 (1997)

Update date:2022-08-03

Topics:

Authors:

Li, Hui-Yin

DeLucca, Indawati

Drummond, Spencer

Boswell, George A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(97)00081-1

An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis.

Full text of DOI:10.1016/S0040-4020(97)00081-1

Products guided by the article

Product name:2-(4-Fluoro-phenyl)-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-4-one

Cas No:188397-74-2

R&D Labs maybe for 188397-74-2

Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan
C-LAB Chemievermittlung GmbH

Contact:+49-9398-993127

Address:Untertorstr. 27
SuZhou Bichal Biological Technology CO.,LTD

Contact:+86-512-68051130

Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
JIN TAN CHENG'EN CHEMICAL CO.,LTD.

Contact:86-519-82116250

Address:NO.102，village Dongfang，conomic development zone
ZHANGJIAGANG FREE TRADE ZONE YONG HAN INTERNATIONAL TRADING CO., LTD(expird)

Contact:86 512 57910558

Address:qianjin M road

Relevant to this article

Racemization kinetics of enantiomeric oxazepams and stereoselective hydrolysis of enantiomeric oxazepam 3-acetates in rat liver microsomes and brain homogenate.

Doi:10.1002/jps.2600781002
(1989)
Palladium(II)-catalyzed formation of γ-butyrolactones from 4-trimethylsilyl-3-alkyn-1-ols: Synthetic and mechanistic aspects

Doi:10.1016/0040-4020(96)00567-4
(1996)
Doi:10.1016/S0040-4020(01)97602-1
(1964)
Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide

Doi:10.1039/c5cc04058b
(2015)
Effect of the CO₂H groups of carboxylated triarylphosphines on (COD) RhCl(PAr₃) -catalyzed isomerization of 1-octen-3-ol under phase transfer conditions

Doi:10.1016/S1381-1169(96)00374-3
(1997)
Doi:10.1021/ja01009a033
(1968)

Article Doi