Asymmetric synthesis and absolute stereochemistry of 4,4-bis(trifluoromethyl)imidazoline based ACAT inhibitors

DOI: 10.1016/S0040-4020(97)00081-1

Source and publish data:

Tetrahedron p. 5359 - 5372 (1997)

Update date:2022-08-03

Topics:

Authors:

Li, Hui-Yin

DeLucca, Indawati

Drummond, Spencer

Boswell, George A.

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Article abstract of DOI:10.1016/S0040-4020(97)00081-1

An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis.

Full text of DOI:10.1016/S0040-4020(97)00081-1

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Product name:2-(4-Fluoro-phenyl)-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-4-one

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