An efficient synthesis of a Galβ1-3GalNAc-serine derivative using β-galactosidase

DOI: 10.1016/S0040-4039(97)00019-1

Source and publish data:

Tetrahedron Letters p. 1211 - 1214 (1997)

Update date:2022-08-05

Topics:

Authors:

Suzuki, Katsuhiko

Fujimoto, Hiroshi

Ito, Yoshiyuki

Sasaki, Takashi

Ajisaka, Katsumi

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Article abstract of DOI:10.1016/S0040-4039(97)00019-1

An efficient route for the synthesis of Galβ1-3GalNAcα1-O-serine derivative was developed using a novel β1-3 galactosidase obtained from Bacillus circulans. By a transglycosylation reaction with pNP-β-Gal 2 as a donor and GalNAcα1-O-Z-Ser-OAll 4 as an acceptor, Galβ1-3GalNAcα-1-O-Z-Ser-OAll 5 was synthesized in 68% yield.

Full text of DOI:10.1016/S0040-4039(97)00019-1

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Product name:N-(benzyloxycarbonyl)-O-(β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-(1->3)-L-serine allyl ester

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