Preparation of naphthoquinone derivatives from plumbagin and their ichthyotoxicity

DOI: 10.1248/cpb.45.437

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 437 - 445 (1997)

Update date:2022-08-04

Topics: Experimental terms Chemical terms

Authors:

Ogihara, Kazuhito

Yamashiro, Rieko

Higa, Matsutake

Yogi, Seiichi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.437

Various naphthoquinone derivatives were prepared from a natural product, 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin); these were mostly substituted at C-3 through carbon-carbon bond formation mediated by a metal- based oxidant such as lead tetraacetate in the presence of various carboxylic acids. The halogenated compounds showed stronger ichthyotoxicity than plumbagin, but other derivatives were less active.

Full text of DOI:10.1248/cpb.45.437

NII-Electronic Library Service

Products guided by the article

Product name:Naphth[2,3-b]oxirene-2,7-dione, 1a,7a-dihydro-6-hydroxy-1a-methyl-

Cas No:188675-38-9

R&D Labs maybe for 188675-38-9

Shanghai Hongbang Medical Technology CO.,. Ltd

Contact:13671516988 /18917636693

Address:Room1, No67 Building, Yongde Road369, Wujing Town, Minhang Districy, Shanghai CIty, China.
Hangzhou Neway Chemicals Co., Ltd.

Contact:+86-571-85095566

Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Melone Pharmaceutical Co., ltd

Contact:+86-411 82593920, 82593631

Address:No 232, JInma Roda, Development Zone, Dalian, China
King Brother Chem Co., Ltd

website:http://www.uvchemkeys.com

Contact:0086-021-58785816

Address:RM2607 Building No.1 Guosheng, Lane 388, Zhongjiang Road, Putuo District, Shanghai 200062 China
Shanghai Yuking Water Soluble Material Tech Co., Ltd

Contact:86-21-68286299

Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China

Relevant to this article

Total synthesis of bafilomycin A₁. 2. The assemblage and completion of the synthesis

Doi:10.1016/0040-4039(95)02351-8
(1996)
Asymmetric synthesis of (R)- and (S)-piperidin-2-yl-phosphonic acid by diastereoselective addition of trialkyl phosphite onto potential iminium salt

Doi:10.1016/S0040-4020(97)00086-0
(1997)
Binuclear Cu(II) and Ni(II) Complexes with Schiff Bases - The Products of Condensation of Amino Alcohols with 2-Phenylhydrazone 1-Phenylbutane-1,2,3- Trione: Synthesis and Magnetic Properties

Doi:10.1023/A:1025611727728
(2003)
Studies on total syntheses of antitumor styryllactones: Stereoselective total syntheses of (+)-goniofufurone, (+)-goniobutenolide A, and (-)-goniobutenolide B

Doi:10.1016/0040-4020(96)00296-7
(1996)
Regioselective opening of epoxides to β-amido alcohols under solid-liquid PTC conditions

Doi:10.1016/S0040-4020(97)00162-2
(1997)
Introduction of a carboxymethylamino (or oxy or thio) group in the 3 position of 2-aryl (or arylmethyl) isoindol-1-ones from α hydroxylactams

Doi:10.1080/00397919708006073
(1997)

Article Doi