Preparation of naphthoquinone derivatives from plumbagin and their ichthyotoxicity

DOI: 10.1248/cpb.45.437

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 437 - 445 (1997)

Update date:2022-08-04

Topics: Experimental terms Chemical terms

Authors:

Ogihara, Kazuhito

Yamashiro, Rieko

Higa, Matsutake

Yogi, Seiichi

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Article abstract of DOI:10.1248/cpb.45.437

Various naphthoquinone derivatives were prepared from a natural product, 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin); these were mostly substituted at C-3 through carbon-carbon bond formation mediated by a metal- based oxidant such as lead tetraacetate in the presence of various carboxylic acids. The halogenated compounds showed stronger ichthyotoxicity than plumbagin, but other derivatives were less active.

Full text of DOI:10.1248/cpb.45.437

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