Inhibition of human leukocyte elastase by functionalized N-aryl-3,3-dihalogenoazetidin-2-ones. Stereospecific synthesis and chiral recognition of dissymmetrically C3-snbstituted β-lactams

DOI: 10.1016/S0957-4166(97)00017-7

Source and publish data:

Tetrahedron Asymmetry p. 739 - 751 (1997)

Update date:2022-07-30

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Authors:

Doucet, Caroline

Vergely, Isabelle

Reboud-Ravaux, Michele

Guilhem, Jean

Kobaiter, Randa

Joyeau, Roger

Wakselman, Michel

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Article abstract of DOI:10.1016/S0957-4166(97)00017-7

(3R)- and (3S)-N-(2-chloromethylphenyl)-3-bromo-3-fluoroazetidin-2-ones 2 were synthesized via the separation of diastereoisomeric phenylglycinol derivatives of the starting 2,3-dibromo-2-fluoropropanoic acid. Acidic hydrolysis of the hydroxyamides led to

Full text of DOI:10.1016/S0957-4166(97)00017-7

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