A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of N(α)-Fmoc-N(α)-(Hmb)amino acids

Article abstract of DOI:10.1016/S0040-4039(97)00303-1

The use of N-Fmoc-N-(Hmb)amino acids for the introduction of the Hmb backbone protection into peptides during solid-phase synthesis is described. An efficient two step synthesis of these derivatives is reported and their coupling to the peptide chain is studied.