A new approach to Hmb-backbone protection of peptides: Synthesis and reactivity of N(α)-Fmoc-N(α)-(Hmb)amino acids

DOI: 10.1016/S0040-4039(97)00303-1

Source and publish data:

Tetrahedron Letters p. 2317 - 2320 (1997)

Update date:2022-08-05

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Authors:

Nicolas, Ernesto

Pujades, Montse

Bacardit, Jordi

Giralt, Ernest

Albericio, Fernando

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Article abstract of DOI:10.1016/S0040-4039(97)00303-1

The use of N-Fmoc-N-(Hmb)amino acids for the introduction of the Hmb backbone protection into peptides during solid-phase synthesis is described. An efficient two step synthesis of these derivatives is reported and their coupling to the peptide chain is studied.

Full text of DOI:10.1016/S0040-4039(97)00303-1

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