A general entry to 2-(2-hydroxyalkyl)piperidines via iterative asymmetric dihydroxylation to cause enantiomeric enhancement

DOI: 10.1016/S0040-4039(97)00643-6

Source and publish data:

Tetrahedron Letters p. 3451 - 3454 (1997)

Update date:2022-08-03

Topics:

Authors:

Takahata, Hiroki

Kubota, Minoru

Momose, Takefumi

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Article abstract of DOI:10.1016/S0040-4039(97)00643-6

Both enantiomers of 2-(2-propenyl)piperidine (1) (76-88% ee), prepared via the first AD of 5-hexenyl azide, underwent the second AD to provide all of the four stereoisomeric 2-(2-hydroxypropyl)piperidines (2) with enantiomeric enhancement (>98 ee). An asy

Full text of DOI:10.1016/S0040-4039(97)00643-6

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