Methylation-ring opening of 3,3-disubstituted 2,3-epoxy alcohols. Synthesis of chiral quaternary fragments for assembly of briaran diterpenes

DOI: 10.1016/S0040-4020(97)00453-5

Source and publish data:

Tetrahedron p. 7429 - 7444 (1997)

Update date:2022-08-02

Topics:

Authors:

Balasubramaniam, Rajiv P.

Moss, David K.

Wyatt, Justin K.

Spence, John D.

Gee, Arvin

Nantz, Michael H.

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Article abstract of DOI:10.1016/S0040-4020(97)00453-5

Two chiral quaternary carbon-containing fragments suitable for elaboration to the briaran diterpenes were obtained by regioselective methylation of functionalized 3,3-disubstituted 2,3-epoxy-1-ols. The factors which favor methylation at the more hindered position of a trisubstituted 2,3-epoxy alcohol were determined.

Full text of DOI:10.1016/S0040-4020(97)00453-5

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