Poly-L-leucine catalysed epoxidation reactions: A short, stereoselective route to chiral α,β-epoxyalcohols

Article abstract of DOI:10.1016/S0040-4039(98)00479-1

Grignard alkylation of epoxyketones (1), (4) from Poly-L-leucine catalysed asymmetric epoxidation of α,β-unsaturated ketones provides a short, stereocontrolled route to optically pure α,β-epoxy tertiary alcohols (2), (3). These epoxyalcohols undergo Payne