The stereoselective synthesis of 4-formyltrinem, a key intermediate for novel trinems

Article abstract of DOI:10.1016/S0040-4039(97)00665-5

The stereoselective synthesis of a protected 4-formyltrinem 8 was accomplished in good yield. This compound is a potential intermediate in the synthesis of a wide range of 4-alkyl and alkenyl substituted trinem antibiotics, as evidenced by its reaction with a series of phosphoranes and phosphonates.