Construction of contiguous chiral tertiary carbon centers by enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand

Article abstract of DOI:10.1016/S0040-4039(97)00695-3

The diastereo- and enantioselective Michael reaction of ketone lithium enolates using a chiral amine ligand (1) was examined. Michael adducts (4) were obtained in excellent chemical yields (95~99%) with high stereoselectivities (syn-4/anti-4: 16/84~1/99;