Synthesis of Modified Tripeptides and Tetrapeptides as Potential Bisubstrate Inhibitors of the Epidermal Growth Factor Receptor Protein Tyrosine Kinase

Article abstract of DOI:10.1002/hlca.19970800304

Thesynthesis of a series of bisubstrate inhibitors of the epiermal growth factor receptor protein kinase (EGF-R PTK) consisting of small peptides linked covalently to adenosine via appropriate triphosphate substitutes is described.Boc-Glu(O'Bu)-Tyr-Leu-OB