Development of new chromanol antagonists of leukotriene D4

DOI: 10.1016/S0960-894X(98)00273-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1791 - 1796 (1998)

Update date:2022-09-26

Topics:

Authors:

Chambers

Antognoli

Cheng Cheng

Marfat Marfat

Pillar Pillar

Shirley Shirley

Watson Watson

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Article abstract of DOI:10.1016/S0960-894X(98)00273-X

By addressing the issues of potency and metabolism in 3, a new series of LTD₄ antagonists represented by (+)-26 was developed which is equipotent to clinical LTD₄ antagonists Zafirlukast (1) and Pranlukast (2).

Full text of DOI:10.1016/S0960-894X(98)00273-X

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