
Tetrahedron Letters p. 4401 - 4404 (1997)
Update date:2022-09-26
Topics: Yield Mass spectrometry (MS) High-performance liquid chromatography (HPLC) Deprotection Protecting group Nuclear Magnetic Resonance (NMR) Purification Macrocyclization Solid-Phase Peptide Synthesis (SPPS) Ring-Closing Metathesis (RCM) Peptide Coupling Aromatic substitution
Roussi, Georges
Zamora, Eduardo Gonzalez
Carbonnelle, Annie-Claude
Beugelmans, Rene
Formation of a biaryl ether bond between the termini of a tetrapeptide containing a highly racemization prone amino acid by the intramolecular SNAr reaction afforded two diastereomeric 16-membered macrocycles along with their respective atropoisomers. The (R,S,R) and its atropoisomer constituted model of chloropeptins I, II, western part.
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Doi:10.1021/jacs.8b05095
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