An efficient synthesis of short-chain sphingomyelin analogs and their susceptibility to hydrolysis catalyzed by sphingomyelinase

Article abstract of DOI:10.1016/S0960-894X(97)00298-9

An efficient synthesis of (D)-erythro-sphingomyelin analogs was achieved v/a highly stereoselective reduction of 3-benzyl-4-(alkynyloxo)-oxazolidinone with diisobutylaluminum phenoxide reagent. The initial velocities of the hydrolysis of the (D)-erythro-d