Novel thombin inhibitors that are based on a macrocyclic tripeptide motif

DOI: 10.1016/S0960-894X(96)00554-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2947 - 2952 (1996)

Update date:2022-07-30

Topics:

Authors:

Greco, Michael N.

Powell, Eugene T.

Hecker, Leonard R.

Andrade-Gordon, Patricia

Kauffman, Jack A.

Lewis, Joan M.

Ganesh, Venkatapathy

Tulinsky, Alexander

Maryanoff, Bruce E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00554-9

A series of macrocyclic α-keto amides containing the D-Phe-Pro-Arg (fPR) motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. Structure-function studies, relating ring size and modifications at the P3 and P1' positions to enzyme inhibition, are described. An X-ray crystallographic study was performed on a ternary complex from 3i, thrombin, and hirugen.

Full text of DOI:10.1016/S0960-894X(96)00554-9

Products guided by the article

Product name:L-Proline, 1-[(2R)-1-oxo-2-[[1-oxo-8-[[(phenylmethoxy)carbonyl]amino]octyl]amino] -4-phenylbutyl]-, 1,1-dimethylethyl ester

Cas No:195302-72-8

R&D Labs maybe for 195302-72-8

Lishui Nanming Chemical Co., Ltd(expird)

Contact:+86-0578-2134101，2697830

Address:No.19 Tongji Road Shuige Industrial zone
TIANJIN FESTO CHEMICAL CO.,LTD(expird)

Contact:86-22-25814570

Address:No.12th,5th Ave.,TEDA,Tianjin,China
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Shifang Taifeng New Flame Retardant Co., Ltd

Contact:02884721008

Address:tingjiang industrial park, hefeng town
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD

Contact:+86-755-82412922

Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District

Relevant to this article

Direct benzylic alkylation via Ni-catalyzed selective benzylic sp ³ C-O activation

Doi:10.1021/ja710944j
(2008)
Synthesis, characterization and molecular recognition of a bis-platinum terpyridine dimer

Doi:10.1039/b716459a
(2008)
New preparation of difluoroiodomethylsulfanylbenzenes and their radical addition to unsaturated compounds initiated by sodium dithionite

Doi:10.1016/j.tet.2007.12.018
(2008)
Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]- 4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole

Doi:10.1016/j.bmcl.2007.12.036
(2008)
First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents

Doi:10.1039/c0ob00616e
(2011)
Salicylamide inhibitors of influenza virus fusion

Doi:10.1016/S0960-894X(00)00335-8
(2000)

Article Doi