Bioorganic and Medicinal Chemistry Letters p. 2947 - 2952 (1996)
Update date:2022-07-30
Topics:
Greco, Michael N.
Powell, Eugene T.
Hecker, Leonard R.
Andrade-Gordon, Patricia
Kauffman, Jack A.
Lewis, Joan M.
Ganesh, Venkatapathy
Tulinsky, Alexander
Maryanoff, Bruce E.
A series of macrocyclic α-keto amides containing the D-Phe-Pro-Arg (fPR) motif were synthesized and evaluated in vitro as inhibitors of human α-thrombin and bovine trypsin. Structure-function studies, relating ring size and modifications at the P3 and P1' positions to enzyme inhibition, are described. An X-ray crystallographic study was performed on a ternary complex from 3i, thrombin, and hirugen.
View MoreSanming Coffer Fine Chemical Industrial Co., Ltd
website:http://www.cofferxm.com/
Contact:+86-598-5853979
Address:Jin-sha Yuan Chuang-ye Park,Hi-Tech Development Zone,Sanming City P.R.China
Shanghai Xinda Pharmaceuticals Co., Ltd.
Contact:86-21-33692333-8008
Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Wuhan Konberd Biotech Co., Ltd.
Contact:+86-27-87205925
Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Contact:86-28-61993785
Address:No.70-13-21, North Section, Erhuan
Jiangsu Willing Bio-Tech Co ltd
website:http://www.willingbio.com/
Contact:+86 18796909136--
Address:No 18 Guoqiao Road
Doi:10.1021/ja710944j
(2008)Doi:10.1039/b716459a
(2008)Doi:10.1016/j.tet.2007.12.018
(2008)Doi:10.1016/j.bmcl.2007.12.036
(2008)Doi:10.1039/c0ob00616e
(2011)Doi:10.1016/S0960-894X(00)00335-8
(2000)
