Organic Letters p. 4794 - 4797 (2017)
Update date:2022-09-26
Topics:
Magné, Valentin
Lorton, Charlotte
Marinetti, Angela
Guinchard, Xavier
Voituriez, Arnaud
(R)-(-)-Rhazinilam has been synthesized in nine steps and 20% overall yield. The key steps involve two metal-catalyzed processes: the enantioselective gold(I)-catalyzed cycloisomerization of an allene-functionalized pyrrole and the palladium-catalyzed hydrocarboxylation of a vinyl moiety with formate as a CO surrogate. This novel strategy represents the shortest and highest yielding enantioselective total synthesis of (-)-rhazinilam.
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Doi:10.1039/d0gc03316b
(2021)Doi:10.1007/BF00908447
()Doi:10.3987/COM-97-S42
(1997)Doi:10.1002/ardp.19973300808
(1997)Doi:10.1021/jo971395g
(1997)Doi:10.1016/S0040-4020(97)10059-X
(1997)
