A New Asymmetric Synthesis of Tricarbonylchromium Complexes of ortho-Substituted Benzaldehydes

Article abstract of DOI:10.1002/hlca.19920750818

ortho-Substituted complexes are obtained via nucleophilic addition of alkyl- and aryllithium reagents to a complex followed by endo-hydride abstraction with triphenylmethyl cation.This sequence, when carried out with a complex affords substituted derivatives (Me, Bu, Ph, vinyl) with high (>/= 97percent) diastereoselectivity and, after hydrolysis, ortho-substituted ((S)-1) complexes of high enantiomeric purity.