An efficient method for the preparation of optically active 4-hydroxy-Δ2-isoxazolines

Article abstract of DOI:10.1016/S0040-4039(97)01596-7

In this letter we report a method for the preparation of optically active 4-hydroxy-Δ²-isoxazolines. This methodology relies on the use of a camphorsultam substituted vinylboronic ester which upon nitrile oxide cycloaddition and oxidation affords the optically active 4-hydroxy-Δ2-isoxazolines in good yield.