Tetrahedron Letters p. 6791 - 6794 (1997)
Update date:2022-08-05
Topics:
Wallace, Richard H.
Liu, Jinchu
Zong
Eddings, Alicia
In this letter we report a method for the preparation of optically active 4-hydroxy-Δ2-isoxazolines. This methodology relies on the use of a camphorsultam substituted vinylboronic ester which upon nitrile oxide cycloaddition and oxidation affords the optically active 4-hydroxy-Δ2-isoxazolines in good yield.
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