Bioorganic and Medicinal Chemistry Letters p. 2569 - 2572 (1999)
Update date:2022-08-05
Topics:
Lowe III, John A.
Qian, Weimin
Volkmann, Robert A.
Heck, Steven
Nowakowski, Jolanta
Nelson, Robert
Nolan, Charles
Liston, Dane
Ward, Karen
Zorn, Stevin
Johnson, Celeste
Vanase, Michelle
Faraci, W. Stephen
Verdries, Kimberly A.
Baxter, James
Doran, Shawn
Sanders, Martin
Ashton, Mike
Whittle, Peter
Stefaniak, Mark
The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics sufficient to provide in vivo inhibition of nNOS activity.
View MoreShanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Zhejiang Genebest Pharmaceutical Co.,Ltd.
Contact:0086-571-63532866
Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Hangzhou TJM Chemical Trade Co., Ltd
Contact:86-571-88223276 86-13388481653
Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
EASYBUYER Co.,LTD.( Chen-Chen )
Contact:+86-21-51816013/51816067
Address:1306,Bldg 8 Hi-Shanghai Center,No.950 Dalian Rd
Zhejiang Tianyu Pharmaceutical Co., Ltd.
Contact:+86-576-84177669, 89189665,89189688,84168770
Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
Doi:10.1248/cpb.48.1558
(2000)Doi:10.1039/d0dt02931a
(2020)Doi:10.1021/jo035750g
(2004)Doi:10.1021/ic970765g
(1997)Doi:10.1007/s00706-020-02674-7
(2020)Doi:10.1039/c2dt32391e
(2013)