An improved synthesis and selective coupling of a hydroxy based photolabile linker for solid phase organic synthesis

Article abstract of DOI:10.1016/S0040-4039(97)10133-2

Photolabile linkers have become an important orthogonal technique for substrate cleavage off the resin in solid-phase organic synthesis. Herein, we report an improved synthesis and selective coupling of a hydroxy based photolinker to a hydroxy based solid-phase resin, thereby removing the necessity for protection or on-resin manipulation.