Chiral 6,7-dihydrooxepin-2(5H)-ones and the azepinone analogues: Conformation and diastereofacial selectivity in addition to the enones

DOI: 10.1016/0040-4039(95)02219-8

Source and publish data:

Tetrahedron Letters p. 633 - 636 (1996)

Update date:2022-08-03

Topics:

Authors:

Sato, Masayuki

Uehara, Fumiaki

Aizawa, Koh-Ichi

Kaneko, Chikara

Satoh, Shun-Ichi

Furuya, Toshio

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Article abstract of DOI:10.1016/0040-4039(95)02219-8

Diastereofacial selectivity in addition to the enones of 6- and 7-substituted dihydrooxepinones was studied. The addition occurred preferentially from the face anti to the substituent and 7-substituted substrates showed higher diastereofacial selectivity than the 6-substituted substrates. An explanation for the observed diastereofacial selectivity is proposed.

Full text of DOI:10.1016/0040-4039(95)02219-8

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