Bioorganic and Medicinal Chemistry p. 2029 - 2040 (1997)
Update date:2022-08-03
Topics:
Mazurov, Anatoly A.
Andronati, Sergei A.
Korotenko, Tamara I.
Sokolenko, Nikolai I.
Dyadenko, Alexei I.
Shapiro, Yury E.
Gorbatyuk, Vitalii Ya.
Voronina, Tatyana A.
For the purpose of rational modification of the TRH molecule, we were pursuing an approach that consists of two steps: (1) 'obligatory' replacement of histidine with glutamine in TRH and (2) the application of conformational constraints for putative bioac
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