Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors

DOI: 10.1016/S0960-894X(97)10081-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2813 - 2818 (1997)

Update date:2022-08-05

Topics:

Authors:

Quan Quan

Pruitt Pruitt

Ellis Ellis

Liauw Liauw

Galemmo Jr.

Stouten Stouten

Wityak Wityak

Knabb Knabb

Thoolen Thoolen

Wong Wong

Wexler Wexler

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Article abstract of DOI:10.1016/S0960-894X(97)10081-6

Factor Xa is an important serine protease in the blood coagulation cascade. It generates thrombin and holds the central position that links the intrinsic and extrinsic activation mechanism in the final common pathway of coagulation. Therefore, inhibition

Full text of DOI:10.1016/S0960-894X(97)10081-6

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