Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V

DOI: 10.1016/S0960-894X(97)10087-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2809 - 2812 (1997)

Update date:2022-08-03

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Authors:

Kaneko, Mitsuaki

Kanie, Osamu

Kajimoto, Tetsuya

Wong, Chi-Huey

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Article abstract of DOI:10.1016/S0960-894X(97)10087-7

The tumor related enzyme N-acetylglucosaminyltransferase V catalyzes the transfer of GlcNAc to OH-6 of branching Man to give complex oligosaccharide structures. A transition state analog inhibitor of this enzyme was designed and a model compound was synthesized to illustrate the feasibility of the synthetic strategy.

Full text of DOI:10.1016/S0960-894X(97)10087-7

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