Synthesis of 2'-O-[(4''-O-stearoyl)-α-L-fucopyranosyl]thymidine: A shimofuridin analogue

Article abstract of DOI:10.1016/S0960-894X(97)10116-0

A synthesis of the title compound has been achieved. The procedure involves a facile preparation of 1'-(3',5'-di-O-benzyl-β-D-ribofuranosyl)-thymine (8) with 1,2-anhydroribofuranose (7) as the glycosyl donor, stereoselective formation of a 1,2-cis (α) interglycoside bond with 4-O-stearoylated pyrimidin-2-yl 1 thio-β-L-fucopyranoside (16) as the glycosyl donor.