Journal of Medicinal Chemistry p. 591 - 601 (1998)
Update date:2022-08-05
Topics:
Thai, Dung L.
Sapko, Michael T.
Reiter, Clara T.
Bierer, Donald E.
Perel, James M.
We report the first asymmetric synthesis of the individual enantiomers of methylphenidate (1). From d-pipecolic acid, the (2R,2'R) and (2S,2'R) enantiomers of 1 were obtained in >99% optical purity while the (2S,2'S) and (2R,2'S) enantiomers of 1 were der
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(1998)
