Bioorganic and Medicinal Chemistry Letters p. 3107 - 3112 (1997)
Update date:2022-08-05
Topics:
Fan
Paternotte
Vermander
Li
Beaujean
Scorneaux
Dumont
Osinski
Claesen
Tulkens
Sonveaux
Seven new ester prodrugs of ampicillin with hydrolysis half-lives ranging from 65 to 308 min were synthesized. The cellular accumulation of two of them (in J774 mouse macrophages) and their activities against intracellular Staphylococcus aureus were determined in comparison with the pivaloyloxymethylester of ampicillin (pivampicillin) and ampicillin. The esters accumulated extensively and were more active than ampicillin in this in vitro system.
View MoreShanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
Shanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Chemsky（shanghai）International Co.,Ltd.
Contact:0
Address:0
Angelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
website:http://www.koningpharm.com
Contact:86-574-87369228
Address:Lingqiao Road
Doi:10.1016/S0960-894X(97)00390-9
(1997)Doi:10.1021/jo00127a008
(1995)Doi:10.1021/om9709805
(1998)Doi:10.1016/S0040-4039(98)00022-7
(1998)Doi:10.1021/tx9701539
(1998)Doi:10.1248/cpb.46.287
(1998)
