Facile synthesis of 3'-C-branched 1,5-anhydrohexitol nucleosides

Article abstract of DOI:10.1080/07328319808004714

The 3'-β-C-branched anhydrohexitol nucleosides have been conveniently synthesised starting from commercially available D-ribose following the reaction sequence: (i) conversion of protected pentofuranose sugar to the corresponding hexopyranosyl nitrosugar (ii) addition of the conjugate base of nitrosugar to formaldehyde to obtain C-branched nitro sugar (iii) removal of nitro group by n-tributyltin hydride treatment and (iv) Mitsunobu type alkylation to build up the nucleobase.

Full text of DOI:10.1080/07328319808004714

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Nucleosides and Nucleotides
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Facile Synthesis of 3′-C-Branched 1,5-
Anhydrohexitol Nucleosides
Nafizal Hossain a & Piet Herdewijn a
a Department of Medicinal Chemistry , Rega Institute for Medical
Research , K. U. Leuven, Minderbroedersstraat 10, Leuven, Belgium
Published online: 22 Aug 2006.
To cite this article: Nafizal Hossain & Piet Herdewijn (1998) Facile Synthesis of 3′-C-Branched
1,5-Anhydrohexitol Nucleosides, Nucleosides and Nucleotides, 17:9-11, 1781-1786, DOI:
10.1080/07328319808004714
To link to this article: http://dx.doi.org/10.1080/07328319808004714
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