Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates

DOI: 10.1016/S0960-894X(98)00011-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 289 - 294 (1998)

Update date:2022-07-30

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Authors:

Lee Lee

Roark Roark

Picard Picard

Sliskovic

Roth Roth

Stanfield

Hamelehle

Bousley Bousley

Krause Krause

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Article abstract of DOI:10.1016/S0960-894X(98)00011-0

Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.

Full text of DOI:10.1016/S0960-894X(98)00011-0

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