Synthesis of N-urethane protected α-alkyl-γ-amino-β-keto-esters from urethane N-carboxyanhydrides (UNCAs)

Article abstract of DOI:10.1016/S0040-4039(98)00026-4

N-protected α-alkyl-γ-amino-β-keto-esters were synthesized from the corresponding N-urethane protected N-carboxyanhydride (UNCAs) by reaction with lithium enolates in fairly good yields. These compounds are candidates for mimicking the transition state an