Synthesis of 1-alkyl-5,6-bis(alkylthio)-l,2-dihydropyridines and their thermally induced conversion into 1-alkyl-3-alkylthio-2H- pyridine-2-thiones

Article abstract of DOI:10.1016/S0040-4039(98)00114-2

Heating of the imidates E-2 (R and R' = alkyl) in refluxing DMF gives derivatives 3 of 1,2-dihydropyridine, which at higher temperatures lose alkane R'H with formation of the cyclic thioamides 4.