Syntheses of 1-Deoxynojirimycin-Trehalamine-Fused and -Linked Compounds and Their Biological Activities

Article abstract of DOI:10.1016/S0040-4020(98)00966-1

1-Deoxynojirimycin-trehalamine-fused and -linked compounds (10,19a and 19b) were synthesized from 1-deoxy-2,3,4,6-tetra-O-benzylnojirimycin and trehazolamine, which was obtained from natural trehazolin as a degradation product. None of these synthetic compounds exceeded 1-deoxynojirimycin in the inhibitory activities towards rat intestinal maltase and yeast α-D-glucosidase. - Keywords: Aminosugars, Carbohydrates, Thioureas, Enzyme inhibitors.