Tetrahedron p. 15167 - 15182 (1998)
Update date:2022-08-02
Topics:
Shiozaki, Masao
Yoshiike, Reiko
Ando, Osamu
Ubukata, Osamu
Haruyama, Hideyuki
1-Deoxynojirimycin-trehalamine-fused and -linked compounds (10,19a and 19b) were synthesized from 1-deoxy-2,3,4,6-tetra-O-benzylnojirimycin and trehazolamine, which was obtained from natural trehazolin as a degradation product. None of these synthetic compounds exceeded 1-deoxynojirimycin in the inhibitory activities towards rat intestinal maltase and yeast α-D-glucosidase. - Keywords: Aminosugars, Carbohydrates, Thioureas, Enzyme inhibitors.
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